| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. FUNCTION: Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ESE-2a; IsoId=Q9UKW6-1; Sequence=Displayed; Name=2; Synonyms=ESE-2b; IsoId=Q9UKW6-2; Sequence=VSP_014510; Name=3; IsoId=Q9UKW6-3; Sequence=VSP_014510, VSP_014511, VSP_014512; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. DOMAIN: The PNT domain acts as a transcriptional activator (By similarity). SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain. SIMILARITY: Contains 1 PNT (pointed) domain. GENE SYNONYMS:ELF5 ESE2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 265 AA; 31263 MW; 43821A79A45768FE CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:3320,
urn:biopax:RelationshipXref:NCBI GENE_2001,
urn:biopax:RelationshipXref:REFSEQ_NP_001230009,
urn:biopax:RelationshipXref:REFSEQ_NP_001230010,
urn:biopax:RelationshipXref:REFSEQ_NP_001413,
urn:biopax:RelationshipXref:REFSEQ_NP_938195,
urn:biopax:UnificationXref:UNIPROT_A8K452,
urn:biopax:UnificationXref:UNIPROT_O95175,
urn:biopax:UnificationXref:UNIPROT_Q8N2K9,
urn:biopax:UnificationXref:UNIPROT_Q96QY3,
urn:biopax:UnificationXref:UNIPROT_Q9UKW5,
urn:biopax:UnificationXref:UNIPROT_Q9UKW6
|
| biopax3:displayName |
ELF5_HUMAN
|
| biopax3:name |
E74-like factor 5,
ELF5,
ESE-2,
Epithelium-restricted ESE-1-related Ets factor,
Epithelium-specific Ets transcription factor 2
|
| biopax3:organism | |
| biopax3:sequence |
MPSLPHSHRVMLDSVTHSTFLPNASFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVHPEYWTKRHVWEWLQFCCDQYKLDTNCISFCNFNISGLQLCSMTQEEFVEAAGLCGEYLYFILQNIRTQGYSFFNDAEESKATIKDYADSNCLKTSGIKSQDCHSHSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRLVYKFGKNAHGWQEDKL
|
| biopax3:standardName |
ETS-related transcription factor Elf-5
|