| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. CATALYTIC ACTIVITY: Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate. CATALYTIC ACTIVITY: Phosphoenolpyruvate + N-acyl-D-mannosamine 6- phosphate + H(2)O = N-acylneuraminate 9-phosphate + phosphate. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 1 AFP-like domain. GENE SYNONYMS:NANS SAS. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 359 AA; 40308 MW; 2E02D47F4F98592F CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:19237,
urn:biopax:RelationshipXref:NCBI GENE_54187,
urn:biopax:RelationshipXref:REFSEQ_NP_061819,
urn:biopax:UnificationXref:UNIPROT_B2RE98,
urn:biopax:UnificationXref:UNIPROT_Q8WUV9,
urn:biopax:UnificationXref:UNIPROT_Q9BWS6,
urn:biopax:UnificationXref:UNIPROT_Q9NR45,
urn:biopax:UnificationXref:UNIPROT_Q9NVD4
|
| biopax3:displayName |
SIAS_HUMAN
|
| biopax3:name |
2.5.1.56,
2.5.1.57,
N-acetylneuraminate synthase,
N-acetylneuraminate-9-phosphate synthase,
N-acetylneuraminic acid phosphate synthase,
N-acetylneuraminic acid synthase,
NANS
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPEGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEELVDNHGKKIKS
|
| biopax3:standardName |
Sialic acid synthase
|