| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. SUBUNIT: Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. TISSUE SPECIFICITY: Expressed in various cancer cell ines. DOMAIN: The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms. SIMILARITY: Belongs to the SDS3 family. SEQUENCE CAUTION: Sequence=BAB14685.1; Type=Erroneous initiation; Sequence=BAB15750.1; Type=Erroneous initiation; GENE SYNONYMS:SUDS3 SAP45 SDS3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 328 AA; 38136 MW; 10A7393B607117EB CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:29545,
urn:biopax:RelationshipXref:NCBI GENE_64426,
urn:biopax:RelationshipXref:REFSEQ_NP_071936,
urn:biopax:UnificationXref:UNIPROT_Q4KMQ5,
urn:biopax:UnificationXref:UNIPROT_Q8N6H0,
urn:biopax:UnificationXref:UNIPROT_Q9H7L9,
urn:biopax:UnificationXref:UNIPROT_Q9H8D2
|
| biopax3:displayName |
SDS3_HUMAN
|
| biopax3:name |
45 kDa Sin3-associated polypeptide,
SUDS3,
Suppressor of defective silencing 3 protein homolog
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:SDS3_HUMAN_1,
urn:biopax:ModificationFeature:SDS3_HUMAN_2,
urn:biopax:ModificationFeature:SDS3_HUMAN_3,
urn:biopax:ModificationFeature:SDS3_HUMAN_4,
urn:biopax:ModificationFeature:SDS3_HUMAN_5,
urn:biopax:ModificationFeature:SDS3_HUMAN_6,
urn:biopax:ModificationFeature:SDS3_HUMAN_7,
urn:biopax:ModificationFeature:SDS3_HUMAN_8
|
| biopax3:organism | |
| biopax3:sequence |
MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYLGQLQRGLFVIRRRSAA
|
| biopax3:standardName |
Sin3 histone deacetylase corepressor complex component SDS3
|