. "SEQUENCE 677 AA; 73840 MW; 5866304B879EC1DE CRC64;"^^ . "FUNCTION: General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. SUBUNIT: TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1. SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=hBRF1; IsoId=Q92994-1; Sequence=Displayed; Name=2; Synonyms=hBRF2; IsoId=Q92994-2; Sequence=VSP_006396, VSP_006397, VSP_006398; Name=3; Synonyms=hBRF3; IsoId=Q92994-3; Sequence=VSP_006396; Name=4; Synonyms=hBRF4; IsoId=Q92994-4; Sequence=VSP_006399, VSP_006400; Name=5; IsoId=Q92994-5; Sequence=VSP_014697; Name=6; IsoId=Q92994-6; Sequence=VSP_043835, VSP_043836; PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TFIIB family. SIMILARITY: Contains 1 TFIIB-type zinc finger. SEQUENCE CAUTION: Sequence=AAC50170.1; Type=Frameshift; Positions=344, 405; GENE SYNONYMS:BRF1 BRF GTF3B TAF3B2 TAF3C. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . . . . . . . . . . . . . . "TF3B_HUMAN"^^ . "BRF1"^^ . "TAF3B2"^^ . "B-related factor 1"^^ . "BRF-1"^^ . "TATA box-binding protein-associated factor, RNA polymerase III, subunit 2"^^ . "hBRF"^^ . "TFIIIB90"^^ . "hTFIIIB90"^^ . . . . . . "MTGRVCRGCGGTDIELDAARGDAVCTACGSVLEDNIIVSEVQFVESSGGGSSAVGQFVSLDGAGKTPTLGGGFHVNLGKESRAQTLQNGRRHIHHLGNQLQLNQHCLDTAFNFFKMAVSRHLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFGEKNHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTLRKRLTEFEDTPTSQLTIDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISSYQDAIEIELENSRPKAKGGLASLAKDGSTEDTASSLCGEEDTEDEELEAAASHLNKDLYRELLGGAPGSSEAAGSPEWGGRPPALGSLLDPLPTAASLGISDSIRECISSQSSDPKDASGDGELDLSGIDDLEIDRYILNESEARVKAELWMRENAEYLREQREKEARIAKEKELGIYKEHKPKKSCKRREPIQASTAREAIEKMLEQKKISSKINYSVLRGLSSAGGGSPHREDAQPEHSASARKLSRRRTPASRSGADPVTSVGKRLRPLVSTQPAKKVATGEALLPSSPTLGAEPARPQAVLVESGPVSYHADEEADEEEPDEEDGEPCVSALQMMGSNDYGCDGDEDDGY"^^ . "Transcription factor IIIB 90 kDa subunit"^^ .