| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. SUBUNIT: Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 (By similarity). Interacts with CTNNAL1. SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92888-1; Sequence=Displayed; Name=2; IsoId=Q92888-2; Sequence=VSP_008125; Note=No experimental confirmation available; Name=3; IsoId=Q92888-3; Sequence=VSP_037766; Note=No experimental confirmation available; TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity. DOMAIN: The DH domain is involved in interaction with CCPG1 (By similarity). PTM: Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 RGSL (RGS-like) domain. SEQUENCE CAUTION: Sequence=CAA70356.1; Type=Frameshift; Positions=904; Sequence=CAA70356.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; GENE SYNONYMS:ARHGEF1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 912 AA; 102435 MW; 1E773D041652190D CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:681,
urn:biopax:RelationshipXref:NCBI GENE_9138,
urn:biopax:RelationshipXref:REFSEQ_NP_004697,
urn:biopax:RelationshipXref:REFSEQ_NP_945328,
urn:biopax:RelationshipXref:REFSEQ_NP_945353,
urn:biopax:UnificationXref:UNIPROT_O00513,
urn:biopax:UnificationXref:UNIPROT_Q8N4J4,
urn:biopax:UnificationXref:UNIPROT_Q92888,
urn:biopax:UnificationXref:UNIPROT_Q96BF4,
urn:biopax:UnificationXref:UNIPROT_Q96F17,
urn:biopax:UnificationXref:UNIPROT_Q9BSB1
|
| biopax3:displayName |
ARHG1_HUMAN
|
| biopax3:name |
115 kDa guanine nucleotide exchange factor,
ARHGEF1,
Sub1.5,
p115-RhoGEF,
p115RhoGEF
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT
|
| biopax3:standardName |
Rho guanine nucleotide exchange factor 1
|