<http://identifiers.org/uniprot/Q92831> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. SUBUNIT: Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity (By similarity). Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed but most abundant in heart and skeletal muscle. DOMAIN: The bromodomain mediates binding to HIV-1 Tat. SIMILARITY: Belongs to the GCN5 family. SIMILARITY: Contains 1 bromo domain. SIMILARITY: Contains 1 N-acetyltransferase domain. GENE SYNONYMS:KAT2B PCAF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 832 AA; 93013 MW; 72F516E8BC00CC0C CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q92831> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q6NSK1> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_003875> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_8850> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A8638> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#displayName> "KAT2B_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#name> "Histone acetyltransferase PCAF"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#name> "Histone acetylase PCAF"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#name> "P/CAF"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#name> "Lysine acetyltransferase 2B"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#name> "P300/CBP-associated factor"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#name> "2.3.1.48"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#name> "KAT2B"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:KAT2B_HUMAN_2> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:KAT2B_HUMAN_1> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:KAT2B_HUMAN_3> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q92831> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Histone acetyltransferase KAT2B"^^<http://www.w3.org/2001/XMLSchema#string> .