| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (By similarity). CATALYTIC ACTIVITY: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. SUBUNIT: Homotetramer (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). PTM: ISGylated. SIMILARITY: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. SIMILARITY: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. GENE SYNONYMS:Acly. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1091 AA; 119728 MW; 660293D027D797DD CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
ACLY_MOUSE
|
| biopax3:name |
2.3.3.8,
ATP-citrate (pro-S-)-lyase,
Acly,
Citrate cleavage enzyme
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:ACLY_MOUSE_1,
urn:biopax:ModificationFeature:ACLY_MOUSE_10,
urn:biopax:ModificationFeature:ACLY_MOUSE_11,
urn:biopax:ModificationFeature:ACLY_MOUSE_12,
urn:biopax:ModificationFeature:ACLY_MOUSE_13,
urn:biopax:ModificationFeature:ACLY_MOUSE_14,
urn:biopax:ModificationFeature:ACLY_MOUSE_15,
urn:biopax:ModificationFeature:ACLY_MOUSE_16,
urn:biopax:ModificationFeature:ACLY_MOUSE_17,
urn:biopax:ModificationFeature:ACLY_MOUSE_18,
urn:biopax:ModificationFeature:ACLY_MOUSE_19,
urn:biopax:ModificationFeature:ACLY_MOUSE_2,
urn:biopax:ModificationFeature:ACLY_MOUSE_20,
urn:biopax:ModificationFeature:ACLY_MOUSE_21,
urn:biopax:ModificationFeature:ACLY_MOUSE_22,
urn:biopax:ModificationFeature:ACLY_MOUSE_3,
urn:biopax:ModificationFeature:ACLY_MOUSE_4,
urn:biopax:ModificationFeature:ACLY_MOUSE_5,
urn:biopax:ModificationFeature:ACLY_MOUSE_6,
urn:biopax:ModificationFeature:ACLY_MOUSE_7,
urn:biopax:ModificationFeature:ACLY_MOUSE_8,
urn:biopax:ModificationFeature:ACLY_MOUSE_9
|
| biopax3:organism | |
| biopax3:sequence |
MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWAHLLQDHPWLLSQSLVVKPDQLIKRRGKLGLVGVNLSLDGVKSWLKPRLGHEATVGKAKGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNTEDIKRHLLVHAPEDKKEVLASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPEGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSATLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMKKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPVVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVAKGAIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQRRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDFVKQHFPATPLLDYALEVEKITTSKKPNLILNVDGFIGVAFVDMLRNCGSFTREEADEYVDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM
|
| biopax3:standardName |
ATP-citrate synthase
|