| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs. CATALYTIC ACTIVITY: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate. ENZYME REGULATION: Inhibited by N-ethylmaleimide (NEM). PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung. DOMAIN: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity). SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. GENE SYNONYMS:AGPAT6 GPAT4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 456 AA; 52071 MW; 5B9DEB2912E989E5 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
GPAT4_HUMAN
|
| biopax3:name |
1-AGP acyltransferase 6,
1-AGPAT 6,
1-acylglycerol-3-phosphate O-acyltransferase 6,
2.3.1.15,
AGPAT6,
Acyl-CoA:glycerol-3-phosphate acyltransferase 4,
GPAT4,
LPAAT-zeta,
Lysophosphatidic acid acyltransferase zeta
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKSLLKIFAWATLRMERGAKEKNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCFLLPLRIALAFTGISLLVVGTTVVGYLPNGRFKEFMSKHVHLMCYRICVRALTAIITYHDRENRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHKDRSRS
|
| biopax3:standardName |
Glycerol-3-phosphate acyltransferase 4
|