| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought provide alink to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity). SUBUNIT: Interacts with TERT, PPP2CA and SMG1. Part of a complex that contains SMG1, SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1. Not detected in complexes that contain unphosphorylated UPF1. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Detected in cytoplasmic mRNA decay bodies (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZPY2-1; Sequence=Displayed; Name=2; IsoId=Q6ZPY2-2; Sequence=VSP_016590, VSP_016591; SIMILARITY: Contains 1 PINc domain. SEQUENCE CAUTION: Sequence=BAC98096.1; Type=Erroneous initiation; GENE SYNONYMS:Smg5 Est1b Kiaa1089. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1017 AA; 114071 MW; 9925688D6FAFAF5C CRC64;
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| biopax3:xref | |
| biopax3:displayName |
SMG5_MOUSE
|
| biopax3:name |
EST1-like protein B,
SMG-5 homolog,
Smg5
|
| biopax3:organism | |
| biopax3:sequence |
MSQGPPPGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKAAYQEVFKPENVSLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLMGFKKPVSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKSETRKLSPSKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLGLTNEDEEECESGYAFLPDLLIFQMAIICLMGVHSLKRAGSKHYSAAIAFTLALFSHLINHVNIRLQAELEEGENPVSAFQSDGTDEPESKEALEKEEPEPEPPTVVPQADEGRKSRKHSRLSCLRRRRRHHPPKAGDDSDLSEGFESDSSHDSAQASDGSDSGSDKSLEGRGTAFDAETDSEMNSQESRSDLEDMEDEEGTRSPAQEPPQARSEVPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTEPNSVASHRPCVNGDMDKPLEPASEDGSESEGSESSNRSCRNERSLQEKLQALMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPASAELQDSGLALCSEVQGLLEGCELPDLPASLLLPEDMALRNLPPLRAAHRRFNFDADRPLLSALEESVVRICCIRSFGHFVARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAEEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLIPDTQALCYHLPLIRQLATSGRFIIIIPRTVIDGLDLLKKEQPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCRQLTLAQGAGEEDPSGMVTIITGLHLDSPSALSGPMQAALQAAAHASVDVKNVLDFYRQWKEIG
|
| biopax3:standardName |
Protein SMG5
|