Q15648

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBUNIT: Interacts with GATA1 and YWHAH (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Binds DNA. SUBCELLULAR LOCATION: Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15648-1; Sequence=Displayed; Name=2; IsoId=Q15648-3; Sequence=VSP_027906, VSP_027907; TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the Mediator complex subunit 1 family. SEQUENCE CAUTION: Sequence=AAC39854.1; Type=Frameshift; Positions=543, 545; Sequence=AAH06517.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAA73867.1; Type=Frameshift; Positions=4; GENE SYNONYMS:MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 1581 AA; 168478 MW; FCE0FE87EF08B887 CRC64;

MED1_HUMAN

urn:biopax:ModificationFeature:MED1_HUMAN_1, urn:biopax:ModificationFeature:MED1_HUMAN_10, urn:biopax:ModificationFeature:MED1_HUMAN_11, urn:biopax:ModificationFeature:MED1_HUMAN_12, urn:biopax:ModificationFeature:MED1_HUMAN_13, urn:biopax:ModificationFeature:MED1_HUMAN_14, urn:biopax:ModificationFeature:MED1_HUMAN_15, urn:biopax:ModificationFeature:MED1_HUMAN_16, urn:biopax:ModificationFeature:MED1_HUMAN_17, urn:biopax:ModificationFeature:MED1_HUMAN_18, urn:biopax:ModificationFeature:MED1_HUMAN_19, urn:biopax:ModificationFeature:MED1_HUMAN_2, urn:biopax:ModificationFeature:MED1_HUMAN_20, urn:biopax:ModificationFeature:MED1_HUMAN_21, urn:biopax:ModificationFeature:MED1_HUMAN_22, urn:biopax:ModificationFeature:MED1_HUMAN_23, urn:biopax:ModificationFeature:MED1_HUMAN_24, urn:biopax:ModificationFeature:MED1_HUMAN_25, urn:biopax:ModificationFeature:MED1_HUMAN_26, urn:biopax:ModificationFeature:MED1_HUMAN_27, urn:biopax:ModificationFeature:MED1_HUMAN_28, urn:biopax:ModificationFeature:MED1_HUMAN_29, urn:biopax:ModificationFeature:MED1_HUMAN_3, urn:biopax:ModificationFeature:MED1_HUMAN_30, urn:biopax:ModificationFeature:MED1_HUMAN_31, urn:biopax:ModificationFeature:MED1_HUMAN_32, urn:biopax:ModificationFeature:MED1_HUMAN_33, urn:biopax:ModificationFeature:MED1_HUMAN_4, urn:biopax:ModificationFeature:MED1_HUMAN_5, urn:biopax:ModificationFeature:MED1_HUMAN_6, urn:biopax:ModificationFeature:MED1_HUMAN_7, urn:biopax:ModificationFeature:MED1_HUMAN_8, urn:biopax:ModificationFeature:MED1_HUMAN_9

MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN