| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. SUBUNIT: Heterodimer; disulfide-linked. Heterodimer of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond (By similarity). SUBCELLULAR LOCATION: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments (By similarity). SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 3 EGF-like domains. SIMILARITY: Contains 1 kringle domain. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/habp2/"; GENE SYNONYMS:HABP2 HGFAL PHBP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 560 AA; 62672 MW; 5C1907230784ACD4 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4798,
urn:biopax:RelationshipXref:NCBI GENE_3026,
urn:biopax:RelationshipXref:REFSEQ_NP_001171131,
urn:biopax:RelationshipXref:REFSEQ_NP_004123,
urn:biopax:UnificationXref:UNIPROT_A8K467,
urn:biopax:UnificationXref:UNIPROT_O00663,
urn:biopax:UnificationXref:UNIPROT_Q14520
|
| biopax3:displayName |
HABP2_HUMAN
|
| biopax3:name |
3.4.21.-,
FSAP,
Factor VII-activating protease,
Factor seven-activating protease,
HABP2,
Hepatocyte growth factor activator-like protein,
Hyaluronan-binding protein 2 27 kDa light chain,
Hyaluronan-binding protein 2 27 kDa light chain alternate form,
Hyaluronan-binding protein 2 50 kDa heavy chain,
Hyaluronan-binding protein 2 50 kDa heavy chain alternate form,
Plasma hyaluronan-binding protein
|
| biopax3:organism | |
| biopax3:sequence |
MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPCGRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVYTQVTKFLNWIKATIKSESGF
|
| biopax3:standardName |
Hyaluronan-binding protein 2
|