<http://identifiers.org/uniprot/Q13569> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 410 AA; 46053 MW; 33752B26EBC789AE CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. CATALYTIC ACTIVITY: Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine. SUBCELLULAR LOCATION: Nucleus. PTM: Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA. SIMILARITY: Belongs to the TDG/mug DNA glycosylase family. WEB RESOURCE: Name=NIEHS-SNPs; URL=\"http://egp.gs.washington.edu/data/tdg/\"; GENE SYNONYMS:TDG. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_003202> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_6996> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q8IUZ6> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q8IZM3> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A11700> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q13569> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#displayName> "TDG_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#name> "TDG"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#name> "Thymine-DNA glycosylase"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#name> "3.2.2.29"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MEAENAGSYSLQQAQAFYTFPFQQLMAEAPNMAVVNEQQMPEEVPAPAPAQEPVQEAPKGRKRKPRTTEPKQPVEPKKPVESKKSGKSAKSKEKQEKITDTFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNMDVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCSSEPCGFSSNGLIESVELRGESAFSGIPNGQWMTQSFTDQIPSFSNHCGTQEQEEESHA"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q13569> <http://www.biopax.org/release/biopax-level3.owl#standardName> "G/T mismatch-specific thymine DNA glycosylase"^^<http://www.w3.org/2001/XMLSchema#string> .