| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). SUBUNIT: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with NFX1. SUBCELLULAR LOCATION: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13310-1; Sequence=Displayed; Name=2; IsoId=Q13310-2; Sequence=VSP_013335; Note=No experimental confirmation available; Name=3; IsoId=Q13310-3; Sequence=VSP_043357; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated. PTM: Arg-518 is dimethylated, probably to asymmetric dimethylarginine. SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family. SIMILARITY: Contains 1 PABC domain. SIMILARITY: Contains 4 RRM (RNA recognition motif) domains. GENE SYNONYMS:PABPC4 APP1 PABP4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 644 AA; 70783 MW; A761488F0B10DF5A CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8557,
urn:biopax:RelationshipXref:NCBI GENE_8761,
urn:biopax:RelationshipXref:REFSEQ_NP_001129125,
urn:biopax:RelationshipXref:REFSEQ_NP_001129126,
urn:biopax:RelationshipXref:REFSEQ_NP_003810,
urn:biopax:UnificationXref:UNIPROT_B1ANQ8,
urn:biopax:UnificationXref:UNIPROT_Q13310,
urn:biopax:UnificationXref:UNIPROT_Q4VC03,
urn:biopax:UnificationXref:UNIPROT_Q6P0N3
|
| biopax3:displayName |
PABP4_HUMAN
|
| biopax3:name |
APP-1,
Activated-platelet protein 1,
Inducible poly(A)-binding protein,
PABP-4,
PABPC4,
Poly(A)-binding protein 4,
iPABP
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:PABP4_HUMAN_1,
urn:biopax:ModificationFeature:PABP4_HUMAN_2,
urn:biopax:ModificationFeature:PABP4_HUMAN_3,
urn:biopax:ModificationFeature:PABP4_HUMAN_4,
urn:biopax:ModificationFeature:PABP4_HUMAN_5,
urn:biopax:ModificationFeature:PABP4_HUMAN_6,
urn:biopax:ModificationFeature:PABP4_HUMAN_7,
urn:biopax:ModificationFeature:PABP4_HUMAN_8,
urn:biopax:ModificationFeature:PABP4_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS
|
| biopax3:standardName |
Polyadenylate-binding protein 4
|