Q13233

FUNCTION: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization. SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38. PTM: Autophosphorylated (By similarity). DISEASE: Defects in MAP3K1 are the cause of 46,XY sex reversal type 6 (SRXY6) [MIM:613762]. SRXY6 is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 SWIM-type zinc finger. GENE SYNONYMS:MAP3K1 MAPKKK1 MEKK MEKK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 1512 AA; 164470 MW; 5CB78242295411D9 CRC64;

M3K1_HUMAN

urn:biopax:ModificationFeature:M3K1_HUMAN_1, urn:biopax:ModificationFeature:M3K1_HUMAN_10, urn:biopax:ModificationFeature:M3K1_HUMAN_11, urn:biopax:ModificationFeature:M3K1_HUMAN_12, urn:biopax:ModificationFeature:M3K1_HUMAN_13, urn:biopax:ModificationFeature:M3K1_HUMAN_14, urn:biopax:ModificationFeature:M3K1_HUMAN_15, urn:biopax:ModificationFeature:M3K1_HUMAN_16, urn:biopax:ModificationFeature:M3K1_HUMAN_17, urn:biopax:ModificationFeature:M3K1_HUMAN_18, urn:biopax:ModificationFeature:M3K1_HUMAN_19, urn:biopax:ModificationFeature:M3K1_HUMAN_2, urn:biopax:ModificationFeature:M3K1_HUMAN_20, urn:biopax:ModificationFeature:M3K1_HUMAN_21, urn:biopax:ModificationFeature:M3K1_HUMAN_22, urn:biopax:ModificationFeature:M3K1_HUMAN_23, urn:biopax:ModificationFeature:M3K1_HUMAN_24, urn:biopax:ModificationFeature:M3K1_HUMAN_25, urn:biopax:ModificationFeature:M3K1_HUMAN_3, urn:biopax:ModificationFeature:M3K1_HUMAN_4, urn:biopax:ModificationFeature:M3K1_HUMAN_5, urn:biopax:ModificationFeature:M3K1_HUMAN_6, urn:biopax:ModificationFeature:M3K1_HUMAN_7, urn:biopax:ModificationFeature:M3K1_HUMAN_8, urn:biopax:ModificationFeature:M3K1_HUMAN_9

MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRRQLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRGGAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW