| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: This is the receptor for interleukin-5. The alpha chain binds to IL5. SUBUNIT: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Membrane-bound; IsoId=Q01344-1; Sequence=Displayed; Name=2; Synonyms=Soluble-S1; IsoId=Q01344-2; Sequence=VSP_001678, VSP_001679; Name=3; Synonyms=Soluble-S2; IsoId=Q01344-3; Sequence=VSP_001680, VSP_001681; TISSUE SPECIFICITY: Expressed on eosinophils and basophils. DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. DOMAIN: The box 1 motif is required for JAK interaction and/or activation. SIMILARITY: Belongs to the type I cytokine receptor family. Type 5 subfamily. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il5ra/"; GENE SYNONYMS:IL5RA IL5R. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 420 AA; 47685 MW; 4E0A5F2838B9C4FE CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:6017,
urn:biopax:RelationshipXref:NCBI GENE_3568,
urn:biopax:RelationshipXref:REFSEQ_NP_000555,
urn:biopax:RelationshipXref:REFSEQ_NP_783851,
urn:biopax:RelationshipXref:REFSEQ_NP_783852,
urn:biopax:RelationshipXref:REFSEQ_NP_783853,
urn:biopax:RelationshipXref:REFSEQ_NP_783854,
urn:biopax:RelationshipXref:REFSEQ_NP_783855,
urn:biopax:UnificationXref:UNIPROT_Q01344,
urn:biopax:UnificationXref:UNIPROT_Q14633,
urn:biopax:UnificationXref:UNIPROT_Q15469,
urn:biopax:UnificationXref:UNIPROT_Q6ISX9
|
| biopax3:displayName |
IL5RA_HUMAN
|
| biopax3:name |
CD125,
CDw125,
IL-5 receptor subunit alpha,
IL-5R subunit alpha,
IL-5R-alpha,
IL-5RA,
IL5RA
|
| biopax3:organism | |
| biopax3:sequence |
MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDEHKPLREWFVIVIMATICFILLILSLICKICHLWIKLFPPIPAPKSNIKDLFVTTNYEKAGSSETEIEVICYIEKPGVETLEDSVF
|
| biopax3:standardName |
Interleukin-5 receptor subunit alpha
|