| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. SUBUNIT: The C-terminus interacts with SHANK1 PDZ domain. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=SSTR2A; IsoId=P30874-1; Sequence=Displayed; Name=B; Synonyms=SSTR2B; IsoId=P30874-2; Sequence=VSP_001922; TISSUE SPECIFICITY: Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. GENE SYNONYMS:SSTR2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 369 AA; 41333 MW; 3B5D7D8A9AC246C6 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11331,
urn:biopax:RelationshipXref:NCBI GENE_6752,
urn:biopax:RelationshipXref:REFSEQ_NP_001041,
urn:biopax:UnificationXref:UNIPROT_A8K3Y0,
urn:biopax:UnificationXref:UNIPROT_P30874,
urn:biopax:UnificationXref:UNIPROT_Q4VBP0,
urn:biopax:UnificationXref:UNIPROT_Q96GE0,
urn:biopax:UnificationXref:UNIPROT_Q96TF2,
urn:biopax:UnificationXref:UNIPROT_Q9BWH1
|
| biopax3:displayName |
SSR2_HUMAN
|
| biopax3:name |
SRIF-1,
SS-2-R,
SS2-R,
SS2R,
SSTR2
|
| biopax3:organism | |
| biopax3:sequence |
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
|
| biopax3:standardName |
Somatostatin receptor type 2
|