| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P25021-1; Sequence=Displayed; Name=2; IsoId=P25021-2; Sequence=VSP_043594; Note=No experimental confirmation available; MISCELLANEOUS: Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Wikipedia; Note=H2 receptor entry; URL="http://en.wikipedia.org/wiki/H2_receptor"; GENE SYNONYMS:HRH2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 359 AA; 40098 MW; 9835AE2BA60B9B0F CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:5183,
urn:biopax:RelationshipXref:NCBI GENE_3274,
urn:biopax:RelationshipXref:REFSEQ_NP_001124527,
urn:biopax:RelationshipXref:REFSEQ_NP_071640,
urn:biopax:UnificationXref:UNIPROT_B5BUP7,
urn:biopax:UnificationXref:UNIPROT_P25021,
urn:biopax:UnificationXref:UNIPROT_Q14464,
urn:biopax:UnificationXref:UNIPROT_Q7Z5R9
|
| biopax3:displayName |
HRH2_HUMAN
|
| biopax3:name |
Gastric receptor I,
H2R,
HH2R,
HRH2
|
| biopax3:organism | |
| biopax3:sequence |
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
|
| biopax3:standardName |
Histamine H2 receptor
|