| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May play a role in the control of gene expression. SUBUNIT: Homodimer. Splice variants heterodimerize. Interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif. Interacts with Epstein-Barr virus EBNA-LP. Interacts with human cytomegalovirus/HHV-5 protein UL123. SUBCELLULAR LOCATION: Nucleus, PML body. Note=Found in the nuclear body, also known as nuclear domain 10 (ND10), PML oncogenic domain (POD), nuclear dots (ND) and KR body. The nuclear body is a nucleoplasmic structure of punctate shape, which varies in size and number. Induction by interferon and may be cell cycle stages modulate the subnuclear localization of the isoforms. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=Sp100-HMG; Synonyms=SpAlt-HMG; IsoId=P23497-1; Sequence=Displayed; Note=Contains an almost complete and highly conserved copy of the DNA-binding HMG1 box; Name=Sp100-A; Synonyms=SP100; IsoId=P23497-2; Sequence=VSP_005978, VSP_005979; Note=Major isoform; Name=Sp100-B; Synonyms=SpAlt-212; IsoId=P23497-3; Sequence=VSP_005980, VSP_005981; Note=Ref.8 (AAL77439) sequence is in conflict in position: 686:T->M; Name=Sp100-C; IsoId=P23497-4; Sequence=VSP_005984; Note=Ref.4 (AAK51202) sequence is in conflict in position: 826:M->T; Name=SpAlt-C; IsoId=P23497-5; Sequence=VSP_005982, VSP_005983; TISSUE SPECIFICITY: Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines. INDUCTION: By interferon. DOMAIN: The HSR domain is important for the nuclear body targeting as well as for the dimerization. DOMAIN: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain. PTM: Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. MISCELLANEOUS: The major isoform Sp100-A, has a calculated MW of 54 kDa, but exhibits aberrant electrophoretic mobilities, with an apparent MW OF 100 kDa. SIMILARITY: Contains 2 HMG box DNA-binding domains. SIMILARITY: Contains 1 HSR domain. SIMILARITY: Contains 1 SAND domain. GENE SYNONYMS:SP100. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 879 AA; 100417 MW; CA55547DE21B2A10 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11206,
urn:biopax:RelationshipXref:NCBI GENE_6672,
urn:biopax:RelationshipXref:REFSEQ_NP_001073860,
urn:biopax:RelationshipXref:REFSEQ_NP_001193630,
urn:biopax:RelationshipXref:REFSEQ_NP_001193631,
urn:biopax:RelationshipXref:REFSEQ_NP_001193632,
urn:biopax:RelationshipXref:REFSEQ_NP_001193633,
urn:biopax:RelationshipXref:REFSEQ_NP_003104,
urn:biopax:UnificationXref:UNIPROT_E9PH61,
urn:biopax:UnificationXref:UNIPROT_O75450,
urn:biopax:UnificationXref:UNIPROT_P23497,
urn:biopax:UnificationXref:UNIPROT_Q13343,
urn:biopax:UnificationXref:UNIPROT_Q8TE34,
urn:biopax:UnificationXref:UNIPROT_Q96F70,
urn:biopax:UnificationXref:UNIPROT_Q96T24,
urn:biopax:UnificationXref:UNIPROT_Q96T95,
urn:biopax:UnificationXref:UNIPROT_Q9NP33,
urn:biopax:UnificationXref:UNIPROT_Q9UE32
|
| biopax3:displayName |
SP100_HUMAN
|
| biopax3:name |
Lysp100b,
Nuclear dot-associated Sp100 protein,
SP100,
Speckled 100 kDa
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:SP100_HUMAN_1,
urn:biopax:ModificationFeature:SP100_HUMAN_10,
urn:biopax:ModificationFeature:SP100_HUMAN_11,
urn:biopax:ModificationFeature:SP100_HUMAN_12,
urn:biopax:ModificationFeature:SP100_HUMAN_13,
urn:biopax:ModificationFeature:SP100_HUMAN_14,
urn:biopax:ModificationFeature:SP100_HUMAN_15,
urn:biopax:ModificationFeature:SP100_HUMAN_16,
urn:biopax:ModificationFeature:SP100_HUMAN_17,
urn:biopax:ModificationFeature:SP100_HUMAN_2,
urn:biopax:ModificationFeature:SP100_HUMAN_3,
urn:biopax:ModificationFeature:SP100_HUMAN_4,
urn:biopax:ModificationFeature:SP100_HUMAN_5,
urn:biopax:ModificationFeature:SP100_HUMAN_6,
urn:biopax:ModificationFeature:SP100_HUMAN_7,
urn:biopax:ModificationFeature:SP100_HUMAN_8,
urn:biopax:ModificationFeature:SP100_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPLESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHRSKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCIQSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCEEHKKKNPDASVKFSEFLKKCSETWKTIFAKEKGKFEDMAKADKAHYEREMKTYIPPKGEKKKKFKDPNAPKRPPLAFFLFCSEYRPKIKGEHPGLSIDDVVKKLAGMWNNTAAADKQFYEKKAAKLKEKYKKDIAAYRAKGKPNSAKKRVVKAEKSKKKKEEEEDEEDEQEEENEEDDDK
|
| biopax3:standardName |
Nuclear autoantigen Sp-100
|