| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. CATALYTIC ACTIVITY: 2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH. COFACTOR: FAD. PATHWAY: Steroid metabolism; cholesterol metabolism. SUBUNIT: Monomer. Interacts directly with FDX1 (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Short; IsoId=P22570-1; Sequence=Displayed; Name=Long; IsoId=P22570-2; Sequence=VSP_003416; Note=Represents 10-20% of all adrenodoxin reductase mRNAs and seems to be inactive; SIMILARITY: Belongs to the ferredoxin--NADP reductase type 1 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fdxr/"; GENE SYNONYMS:FDXR ADXR. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 491 AA; 53837 MW; 15D07E714F592C9D CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:3642,
urn:biopax:RelationshipXref:NCBI GENE_2232,
urn:biopax:RelationshipXref:REFSEQ_NP_004101,
urn:biopax:RelationshipXref:REFSEQ_NP_077728,
urn:biopax:UnificationXref:UNIPROT_P22570,
urn:biopax:UnificationXref:UNIPROT_Q13716,
urn:biopax:UnificationXref:UNIPROT_Q4PJI0,
urn:biopax:UnificationXref:UNIPROT_Q9BU12
|
| biopax3:displayName |
ADRO_HUMAN
|
| biopax3:name |
1.18.1.2,
AR,
Adrenodoxin reductase,
FDXR,
Ferredoxin reductase,
Ferredoxin--NADP(+) reductase
|
| biopax3:organism | |
| biopax3:sequence |
MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVVGSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTVPELREAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH
|
| biopax3:standardName |
NADPH:adrenodoxin oxidoreductase, mitochondrial
|