| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. POLYMORPHISM: The Del322-325 variant has a significant loss of function. It is approximately 10 times more frequent in African- Americans compared with Caucasians (allele frequencies 0.381 versus 0.040). SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily. SEQUENCE CAUTION: Sequence=AAA35513.1; Type=Frameshift; Positions=270, 296, 300; Sequence=AAC78723.1; Type=Frameshift; Positions=270, 296, 300; GENE SYNONYMS:ADRA2C ADRA2L2 ADRA2RL2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 462 AA; 49522 MW; E1EF9CA21E7F6EDA CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
ADA2C_HUMAN
|
| biopax3:name |
ADRA2C,
Alpha-2 adrenergic receptor subtype C4,
Alpha-2C adrenoceptor,
Alpha-2C adrenoreceptor,
Alpha-2CAR
|
| biopax3:organism | |
| biopax3:sequence |
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
|
| biopax3:standardName |
Alpha-2C adrenergic receptor
|