| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
CATALYTIC ACTIVITY Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.CATALYTIC ACTIVITY Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.CATALYTIC ACTIVITY 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.CATALYTIC ACTIVITY Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SUBUNIT Pre-integration complex interacts with human HMGA1. Matrix protein p17 is a trimer. Interacts with gp120 and human BAF. Capsid is a homodimer. Interacts with human PPIA/CYPA. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. The reverse transcriptase is a heterodimer of p66 RT and p51 RT (RT p66/p51). Heterodimerization of RT is essential for DNA polymerase activity. Despite the sequence identities, p66 RT and p51 RT have distinct folding. Integrase is a homodimer and possibly can form homotetramer. Integrase interacts with human SMARCB1/INI1 and human PSIP1/LEDGF isoform 1. Integrase interacts with human KPNA3; this interaction might play a role in nuclear import of the pre-integration complex (By similarity). Integrase interacts with human NUP153; this interaction might play a role in nuclear import of the pre-integration complex.MISCELLANEOUS The reverse transcriptase is an error-prone enzyme that lacks a proof-reading function. High mutations rate is a direct consequence of this characteristic. RT also displays frequent template switching leading to high recombination rate. Recombination mostly occurs between homologous regions of the two copackaged RNA genomes. If these two RNA molecules derive from different viral strains, reverse transcription will give rise to highly recombinated proviral DNAs.MISCELLANEOUS HIV-1 lineages are divided in three main groups, M (for Major), O (for Outlier), and N (for New, or Non-M, Non-O). The vast majority of strains found worldwide belong to the group M. Group O seems to be endemic to and largely confined to Cameroon and neighboring countries in West Central Africa, where these viruses represent a small minority of HIV-1 strains. The group N is represented by a limited number of isolates from Cameroonian persons. The group M is further subdivided in 9 clades or subtypes (A to D, F to H, J and K).MISCELLANEOUS Resistance to inhibitors associated with mutations are observed both in viral protease and in reverse transcriptase. Most of the time, single mutations confer only a modest reduction in drug susceptibility. Combination of several mutations is usually required to develop a high-level drug resistance. These mutations are predominantly found in clade B viruses and not in other genotypes. They are listed in the clade B representative isolate HXB2 (AC P04585).SIMILARITY Contains 2 CCHC-type zinc fingers.SIMILARITY Contains 1 integrase catalytic domain.SIMILARITY Contains 1 integrase-type DNA-binding domain.SIMILARITY Contains 1 integrase-type zinc finger.SIMILARITY Contains 1 peptidase A2 domain.SIMILARITY Contains 1 reverse transcriptase domain.SIMILARITY Contains 1 RNase H domain.
|
| biopax3:xref | |
| biopax3:displayName |
gag-pol
|
| biopax3:name |
UniProt:P12497 gag-pol
|
| biopax3:organism |