Linked Life Data

O08537

Source:http://identifiers.org/uniprot/O08537

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1, UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with DYX1C1. Interacts with PRMT2 (By similarity). SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist; Name=1; Synonyms=Beta-1; IsoId=O08537-1; Sequence=Displayed; Name=2; Synonyms=Beta-2; IsoId=O08537-2; Sequence=VSP_003693; Name=3; Synonyms=Beta-5A; IsoId=O08537-4; Sequence=VSP_003696; Note=Corresponds to exons 5 and 6 deletion (PubMed:9685228); Name=4; IsoId=O08537-6; Sequence=VSP_042429, VSP_042430; Note=Corresponds to exon 5 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available; Name=5; IsoId=O08537-7; Sequence=VSP_042431, VSP_042432; Note=Corresponds to exon 6 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available; TISSUE SPECIFICITY: Expressed in prostate, ovary, Leydig cells and in epithelium of the efferent ductules and of the initial segment of the epididymis. INDUCTION: Isoforms 1 and 2 are down-regulated by 17-beta- estradiol. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. SEQUENCE CAUTION: Sequence=AAC17919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI41076.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI45330.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAL15175.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC35719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC35770.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:Esr2 Estrb Nr3a2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 530 AA; 59070 MW; BEFA25F62650A8D4 CRC64;
biopax3:xref
biopax3:displayName
ESR2_MOUSE
biopax3:name
ER-beta, Esr2, Nuclear receptor subfamily 3 group A member 2
biopax3:entityFeature
biopax3:organism
biopax3:sequence
MEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVHCLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ
biopax3:standardName
Estrogen receptor beta