| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. SUBUNIT: Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. PTM: Serine phosphorylated; followed by proteasome-dependent degradation. SIMILARITY: Belongs to the NF-kappa-B inhibitor family. SIMILARITY: Contains 6 ANK repeats. SEQUENCE CAUTION: Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351; GENE SYNONYMS:NFKBIE IKBE. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 500 AA; 52864 MW; 45E726E7A0E8D478 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
IKBE_HUMAN
|
| biopax3:name |
I-kappa-B-epsilon,
IkB-E,
IkB-epsilon,
IkappaBepsilon,
NF-kappa-BIE,
NFKBIE
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRGGGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAARRSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLCTD
|
| biopax3:standardName |
NF-kappa-B inhibitor epsilon
|