| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:cellularLocation | |
| biopax3:comment |
This proton-monocarboxylate cotransporter catalyzes the rapid transport across the plasma membrane of many monocarboxylates, including lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate |CITS: [8124722]|. Expression of the protein is substantially induced by substrates, such as butyrate |CITS: [11882670]|. The cDNA has been cloned, and the |FRAME: HS08049| gene was mapped to chromosome 1p13.2-p12 |CITS: [7835905]|. |FRAME: HS08049| is abundant in erythrocytes, cardiac muscle, and basolateral intestinal epithelium. In skeletal muscle it is restricted to mitochondria-rich myocytes |CITS: [8124722]|. Mutations in the gene have been shown in patients suffering from symptomatic deficiency in lactate transport |CITS: [10590411]|. A single |FRAME: PHE| to |FRAME:CYS| substitution in |FRAME: HS08049| converts it to a mevalonate transporter |CITS:[1429658][8124722]|.
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
MCT 1
|
| biopax3:name |
Solute carrier family 16 member 1
|
| biopax3:entityReference | |
| biopax3:standardName |
Monocarboxylate transporter 1
|