| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
This enzyme is a member of the SULT enzyme family, and the SULT1 (phenol sulfotransferase) subfamily. It is widely expressed in tissues, including liver, intestine and brain. In humans, sulfation modulates the activity and facilitates the transport of catecholamines and other biogenic amines. SULT1A3 prefers endogenous catecholamines as substrates and is highly expressed in the gastrointestinal tract (in |CITS: [9855620]|). Sulfation is a major metabolic detoxification mechanism |CITS: [10336855]|. The crystal structure of this enzyme has been reported |CITS: [10543947] [16083857]|. The enzyme has been purified from human brain |CITS: [3860259]|. Recombinant enzyme from brain cDNA has been expressed in COS-7 cells |CITS: [3860259]|, recombinant enzyme from breast carcinoma T47D cell cDNA has been expressed in <i>Escherichia coli</i> |CITS: [8565785]|, recombinant enzyme from liver cDNA has been expressed in <i>Escherichia coli</i> |CITS: [9855620]|, and recombinant enzyme from platelet cDNA has been expressed in <i>Saccharomyces cerevisiae</i>, COS-7 and V79 cells |CITS: [10336855]|. It was also expressed in <i>Escherichia coli</i> and purified. |CITS: [10336855]|. The molecular mass of the native dimeric enzyme was determined by a combination of dynamic light scattering, and sedimentation equilibrium experiments |CITS: [10336855]|.
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| biopax3:component | |
| biopax3:componentStoichiome... | |
| biopax3:xref |
http://identifiers.org/pubmed/10720750,
http://identifiers.org/pubmed/11154739,
http://identifiers.org/pubmed/11535246,
http://identifiers.org/pubmed/12228221,
http://identifiers.org/pubmed/12424257,
http://identifiers.org/pubmed/7695643,
http://identifiers.org/pubmed/7829089,
http://identifiers.org/pubmed/8117269,
http://identifiers.org/pubmed/8187949,
http://identifiers.org/pubmed/8363592,
http://identifiers.org/pubmed/9034160,
urn:biopax:RelationshipXref:PROTEIN DATA BANK_1CJM,
urn:biopax:RelationshipXref:PROTEIN DATA BANK_2A3R
|
| biopax3:dataSource | |
| biopax3:displayName |
M-PST
|
| biopax3:name |
HAST3,
catecholamine-sulfating phenol sulfotransferase,
monoamine-sulfating phenol sulfotransferase SULT1A3,
placental estrogen sulfotransferase,
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3,
sulfotransferase, monoamine-preferring,
thermolabile phenol sulfotransferase
|
| biopax3:standardName |
sulfotransferase 1A3/1A4
|