Biochem. Biophys. Res. Commun.

Human astrin is a newly identified microtubule-associated protein, which is highly expressed in the testis. Silencing of astrin has resulted in growth arrest and apoptotic cell death. In this study, we describe the cloning and genomic structure of mastrin, the mouse counterpart to astrin. The overall mouse mastrin amino-acid sequence is 66% identical to human astrin. Mastrin protein was demonstrated to localize to mitotic spindles during mitosis. Genomic clones containing mastrin gene were isolated; the gene was found to have 24 exons spanning 24kb of genomic DNA. Deletion analysis of 5(')-flanking sequences demonstrated that the first 120bp proximal to the TATA-less promoter region is necessary for minimal transcription of the mouse mastrin gene.

Source:http://purl.uniprot.org/citations/12893248

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http://purl.uniprot.org/cit...	rdfs:comment	Human astrin is a newly identified microtubule-associated protein, which is highly expressed in the testis. Silencing of astrin has resulted in growth arrest and apoptotic cell death. In this study, we describe the cloning and genomic structure of mastrin, the mouse counterpart to astrin. The overall mouse mastrin amino-acid sequence is 66% identical to human astrin. Mastrin protein was demonstrated to localize to mitotic spindles during mitosis. Genomic clones containing mastrin gene were isolated; the gene was found to have 24 exons spanning 24kb of genomic DNA. Deletion analysis of 5(')-flanking sequences demonstrated that the first 120bp proximal to the TATA-less promoter region is necessary for minimal transcription of the mouse mastrin gene.	lld:uniprot
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http://purl.uniprot.org/cit...	uniprot:name	Biochem. Biophys. Res. Commun.	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:author	Yang Y.-C.	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:author	Huang C.-J.	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:author	Chen C.-Y.	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:author	Chang M.-S.	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:author	Fan C.-C.	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:author	Chu J.-M.	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:date	2003	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:pages	491-497	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:title	Expression and promoter analysis of mouse mastrin gene.	lld:uniprot
http://purl.uniprot.org/cit...	uniprot:volume	307	lld:uniprot
http://purl.uniprot.org/cit...	dc-term:identifier	doi:10.1016/S0006-291X(03)01220-8	lld:uniprot
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