S1 region attaches the virion to the cell membrane by interacting with porcine ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
Subject | Predicate | Object | Context |
---|---|---|---|
http://purl.uniprot.org/SHA... | rdf:type | uniprot:Function_Annotation | lld:uniprot |
http://purl.uniprot.org/SHA... | rdfs:comment | S1 region attaches the virion to the cell membrane by interacting with porcine ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity). | lld:uniprot |
uniprot-protein:P18450 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
uniprot-protein:P33470 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
uniprot-protein:P07946 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
uniprot-protein:P27655 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
uniprot-protein:P24413 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |
uniprot-protein:Q01977 | uniprot:annotation | http://purl.uniprot.org/SHA... | lld:uniprot |