. "Edited: Shamovsky, V, 2011-08-12"^^ . "Authored: Shamovsky, V, 2009-12-16"^^ . "Reviewed: Gillespie, ME, 2010-02-27"^^ . "NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression."^^ . . . . . . . . . "TAK1 activates NFkB by phosphorylation and activation of IKKs complex"^^ . . . . . . . .