<http://www.reactome.org/biopax/48887Pathway619> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#Pathway> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Garapati, P V, 2008-12-16 11:12:19"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Garapati, P V, 2008-12-16 11:12:19"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#comment> "The Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation events that are positively regulated by CD28 or indirectly through IL-2. PD-1 ligation inhibits the induction of the cell survival factor Bcl-xL and the expression of transcription factors associated with effector cell function, including GATA-3, Tbet, and Eomes. PD-1 exerts its inhibitory effects by bringing phosphatases SHP-1 and SHP-2 into the immune synapse, leading to dephosphorylation of CD3-zeta chain, PI3K and AKT."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/18759926> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/18173375> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_19324_1> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_389948> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#displayName> "PD-1 signaling"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#pathwayComponent> <http://www.reactome.org/biopax/48887BiochemicalReaction2327> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#pathwayComponent> <http://www.reactome.org/biopax/48887BiochemicalReaction2328> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#pathwayComponent> <http://www.reactome.org/biopax/48887BiochemicalReaction2325> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#pathwayComponent> <http://www.reactome.org/biopax/48887BiochemicalReaction2326> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#pathwayOrder> <http://www.reactome.org/biopax/48887PathwayStep2998> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#pathwayOrder> <http://www.reactome.org/biopax/48887PathwayStep2995> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#pathwayOrder> <http://www.reactome.org/biopax/48887PathwayStep2996> .
<http://www.reactome.org/biopax/48887Pathway619> <http://www.biopax.org/release/biopax-level3.owl#pathwayOrder> <http://www.reactome.org/biopax/48887PathwayStep2997> .