. "Authored: Jassal, B, 2011-10-14"^^ . "Edited: Jassal, B, 2011-10-14"^^ . "Reviewed: D'Eustachio, P, 2012-05-14"^^ . "Sulfatase activity requires a unique posttranslational modification (PTM) of a catalytic cysteine residue into a formylglycine. This modification is impaired in patients with multiple sulfatase deficiency (MSD) due to defects in the SUMF1 (sulfatase-modifying factor 1) gene responsible for this PTM. SUMF2 can inhibit the activity of SUMF1 thereby providing a mechanism for the regulation of sulfatase activation (Ghosh 2007, Diez-Roux & Ballabio 2005)."^^ . . . . . . . "The activation of arylsulfatases"^^ . . . . . .