. "Reviewed: Cooper, HM, 2010-02-16"^^ . "Edited: Garapati, P V, 2008-07-30 10:24:23"^^ . "Authored: Garapati, P V, 2008-07-16 14:42:16"^^ . "Netrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse and humans: Netrin-1, -3/NTL2, -4/h and G-Netrins. Netrin-1 is the most studied member of the family and has been shown to play a crucial role in neuronal navigation during nervous system development mainly through its interaction with its receptors DCC and UNC5. Members of the Deleted in colorectal cancer (DCC) family- which includes DCC and Neogenin in vertebrates- mediate netrin-induced axon attraction, whereas the C. elegans UNC5 receptor and its four vertebrate homologs Unc5a-Unc5d mediate repulsion."^^ . . . . . . . "Netrin-1 signaling"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .