. "Reviewed: Widlak, P, 2008-04-25 14:11:44"^^ . "DNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in Widlak and Garrard, 2005). These endonucleases cleave chromatin producing 3'-hydroxyl groups and 5'-phosphate residues. 50-300 kb cleavage products are produced followed by internucleosomal DNA fragmentation. Although the activities of DFF and Endo G are similar, they reside in different locations within the cell and are regulated in different ways."^^ . "Edited: Matthews, L, 2008-05-18 15:19:12"^^ . "Authored: Matthews, L, 2008-04-25 11:29:13"^^ . . . . . . . "Apoptosis induced DNA fragmentation"^^ . . . .