. "NICD translocates to the nucleus and assembles into a ternary complex with the CSL (human RBPJ i.e. CBF1/ fly Suppressor of Hairless/ worm Lag1) DNA-binding protein and the Mastermind co-activator. This complex activates the transcription of downstream gene targets like HES (Hairy/Enhancer of Split) and HES-related (HRT, also named CHF, HEY, HESR, gridlock) genes."^^ . "Authored: Jassal, B, 2005-01-10 12:51:46"^^ . . . . . "NICD traffics to nucleus"^^ . . . . . . . .