. "Reviewed: Huang, Tao, 2012-05-14"^^ . "Authored: Orlic-Milacic, M, 2012-04-04"^^ . "Edited: Jassal, B, 2012-04-10"^^ . "E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007, Nagano et al. 2007) and SMURF2 (Bonni et al. 2001) ubiquitinate SKI/SKIL transcriptional repressors bound to activated SMAD2/3. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL. The role of SMURF2 was inferred from experiments involving human proteins only."^^ . . . . . . . . "Ubiquitination of SKI/SKIL by RNF111/SMURF2"^^ . "6.3.2.19"^^ . . . . . . .