. "Reviewed: Kunapuli, SP, 2010-06-07"^^ . "Authored: Akkerman, JW, 2009-06-03"^^ . "Edited: Jupe, S, 2010-06-07"^^ . "Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission."^^ . . . . . . "Soluble guanylate cyclase converts GTP to cGMP"^^ . "4.6.1.2"^^ . . . .