. "Reviewed: Chang, E, 2008-05-21 00:05:41"^^ . "Edited: Matthews, L, 2008-02-03 20:50:13"^^ . "Authored: Jakobi, R, 2008-02-05 11:04:14"^^ . "Edited: Matthews, L, 2008-05-23 07:02:49"^^ . "p21-activated protein kinase (PAK-2), also known as gamma-PAK, is cleaved by caspase-3 during apoptosis and plays a role in regulating cell death. Cleavage produces two peptides; 1-212 containing most of the regulatory domain and 213-524 containing 34 amino acids of the regulatory domain as well as the catalytic domain (Walter et al., 1998). Proteolytic cleavage of PAK by caspase-3 creates the constitutively active PAK-2p34 fragment (Jakobi et al., 2003). Evidence for this reaction comes from experiments using both human and rabbit proteins."^^ . . . . . . . "Cleavage of PAK-2 at 212"^^ . "3.4.22"^^ . . . .