. "Cytosolic acetyl-CoA carboxylase 1 (ACACA) catalyzes the reaction of bicarbonate, ATP, and acetyl-CoA to form malonyl-CoA, ADP, and orthophosphate. The reaction is positively regulated by citrate. The human ACACA cDNA has been cloned (Abu-Elheiga et al. 1995) and the biochemical properties of the human enzyme have recently been described (Cheng et al. 2007; Locke et al. 2008). Four ACACA isoforms generated by alternative splicing have been identified as mRNAs - the protein product of the first has been characterized experimentally."^^ . "Authored: Gopinathrao, G, 2003-10-03 00:00:00"^^ . . . . . . . . "Formation of Malonyl-CoA from Acetyl-CoA (liver)"^^ . "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate"^^ . "6.4.1.2"^^ . . . . . . .