. "Reviewed: Coqueret, O, 2006-10-06 08:59:06"^^ . "Authored: Pagano, M, 2006-09-19 08:23:10"^^ . "Edited: Matthews, L, 2006-09-28 04:25:14"^^ . "Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK kinase activity. The association of p21/p27 with the Cyclin A/E:Cdk2 complex prevents CAK mediated phosphorylation of Cdk2 (Aprelikova et al., 1995)."^^ . . . . . . "CAK-mediated phosphorylation of Cyclin A:Cdk2"^^ . . . . .