. "At the beginning of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present. At the end of this reaction, 1 molecule of 'DNA polymerase alpha:primase', and 1 molecule of 'RNA primer-DNA primer:origin duplex with DNA damage' are present.

This reaction takes place in the 'nucleus'.
"^^ . . . . . "Detection of damage during initiation of DNA synthesis in S-phase"^^ . . . .