. "Reviewed: Sudol, M, 2012-02-03"^^ . "Authored: D'Eustachio, P, 2012-02-03"^^ . "Edited: D'Eustachio, P, 2011-12-30"^^ . "YWHAE (14-3-3 epsilon) binds phosphorylated WWTR1 (TAZ), sequestering it in the cytosol. Structural studies indicate that the active form of YWHAE (14-3-3 epsilon) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with WWTR1 (TAZ) is unknown and has been annotated arbitrarily here to involve one WWTR1 (TAZ) molecule and a YWHAE(14-3-3 epsilon) dimer. Phosphorylation of serine residue 127 of WWTR1 (TAZ) appears to be critical for YWHAE (14-3-3 epsilon) binding (Kanai et al. 2000; Lei et al. 2008)."^^ . . . . . . . . "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)"^^ . . . .