<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Akkerman, JW, 2009-06-03"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Jupe, S, 2009-09-09"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#comment> "The active form of G protein alpha subunit q (Gq-alpha) was found to activate phospholipase C beta-1 (PLC-beta1), in investigations using bovine membranes. Subsequently, all 4 human isoforms have been shown to be activated by Gq, though activation of PLCbeta-4 is limited. In recombinant assays, several activated rat G alpha q family members were found to stimulate human PLC-beta isoforms with the same rank order of decreasing potency. PLC-beta1 stimulation was slightly more than for PLC-beta3; PLC-beta3 stimulation was 10-fold greater than for beta-2. PLC-beta2 is expressed specifically in hematopoietic cells. PLC-beta acts directly on Gq to accelerate hydrolysis of bound GTP, thus PLC-betas are GTPase activating proteins (GAPs). The crystal structure of the C-terminal region from Turkey PLC-beta, revealed a novel fold composed almost entirely of three long helices forming a coiled-coil that dimerizes along its long axis in an antiparallel orientation. The extent of the dimer interface and gel exclusion chromatography data suggest that PLC-betas are functionally dimeric."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Jupe, S, 2009-06-03"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_398188> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/15705797> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/16182515> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_19270_5> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/11753430> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#displayName> "PLC beta is activated by G alpha (q)"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Complex1037> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein11533> .
<http://www.reactome.org/biopax/48887BiochemicalReaction3516> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex4469> .