. "Authored: Jassal, B, 2009-01-07 14:37:24"^^ . "Edited: Jassal, B, 2009-01-07 14:37:24"^^ . "Reviewed: D'Eustachio, P, 2009-03-02 09:24:35"^^ . "The orexin (hypocretin) neuropeptides (A and B) both derive from a 131 residue precursor, prepro-orexin peptide (Sakurai T et al, 1999). Orexin A (Takai T et al, 2006) binds preferentially to the orphan GPCR orexin 1 receptor (Sakurai T et al, 1998). This activated complex can transduce its signal via the Gq class of G protein."^^ . . . . . . . . "Orexin 1 receptor can bind orexin-A neuropeptide"^^ . . . .