. "Edited: D'Eustachio, P, 2008-09-01 11:58:31"^^ . "Reviewed: Bockaert, J, 2008-09-01 12:04:13"^^ . "Authored: Jassal, B, 2008-08-21 14:07:16"^^ . "The orphan nociceptin (ORL1) receptor (Mollereau C et al, 1994) is most closely related to opioid receptors on structural (sequence) and functional grounds but is not a typical opioid receptor. It may play a role in instinctive behaviours and emotions. Its natural ligand is nociceptin (orphanin FQ) (Mollereau C et al, 1996), a 17 amino acid neuropeptide which acts as a potent anti-analgesic. Both receptor and ligand are widely expressed in the CNS."^^ . . . . . . . . "Nociceptin receptor binds to nociceptin"^^ . . . .