. "Authored: Garapati, P V, 2011-07-11"^^ . "Edited: Garapati, P V, 2011-07-11"^^ . "Reviewed: R\u00F6nnstrand, L, 2011-08-22"^^ . "Binding of the SCF dimer to KIT rapidly triggers KIT dimerization and autophosphorylation. It is thought that one SCF dimer binds simultaneously to two KIT monomers. The fourth Ig-like domain of KIT contains the dimerisation site; deletion of this domain completely abolishes KIT dimerisation and subsequent downstream signaling (Edling et al. 2007, Blechman et al. 1995). KIT dimerization is a crucial initial step in the SCF signal transduction process."^^ . . . . . . . . . . . . "Dimerization of KIT upon SCF binding"^^ . . . .