. "Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27"^^ . "Reviewed: Heldin, CH, 2008-11-23 19:29:34"^^ . "Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27"^^ . "Nck is a widely expressed protein consisting exclusively of SH2 and SH3 domains. With its SH2 doamin Nck interacts with Tyr571 of the PDGF beta-receptor and it also interacts with the alpha-receptor, but the sites of interaction has not been determined. Nck is involved in the activation of the JNK serine/threonine kinase through interaction with the serine/threonine kinases PAK1 and NIK."^^ . . . . . . . . "Nck binds to the active PDGF receptor"^^ . . . .