. "Reviewed: Zheng, B, 2009-10-20"^^ . "Edited: Jassal, B, 2008-11-19 15:14:38"^^ . "Authored: Katajisto, P, Makela, T, Wu, J, 2008--1-1-"^^ . "TSC2 (in the TSC complex) functions as a GTPase-activating protein and stimulates the intrinsic GTPase activity of a small G-protein Rheb. This results in the conversion of Rheb-GTP into Rheb-GDP and in the inhibition of the mTOR activation by GTP-bound Rheb (Inoki K et al, 2003; Tee AR et al, 2003)."^^ . . . . . . . "TSC2 activates intrinsic GTPase activity of Rheb"^^ . . . .