. "Authored: Ray, KP, 2010-05-17"^^ . "Edited: Jupe, S, 2010-08-06"^^ . "Reviewed: Lopez, AF, 2010-09-06"^^ . "Reviewed: Hercus, TR, 2010-09-06"^^ . "The Interleukin-5 receptor alpha subunit (IL5Ra) has a single transmembrane domain, a glycosylated extracellular domain and a short (58 amino acids) cytoplasmic tail, containing no tyrosine kinase domain. It binds IL-5 with a relatively low affinity and is not capable of signaling by itself. The alpha subunit has alternatively spliced soluble forms that are capable of binding IL-5 and act as natural antagonists of IL-5 signaling. The cytoplasmic domain of the alpha chain appears to be critical for IL-5 signaling (Takaki et al. 1993). IL5R alpha chain was found to be constitutively associated with JAK2 (Ogata et al. 1998); the same study found that JAK1 was constitutively associated with Bc, though the consensus is that JAK2 is associated with Bc."^^ . . . . . . . . "Interleukin-5 receptor alpha subunit binds Interleukin-5"^^ . . . .