. "Edited: Jupe, S, 2010-05-17"^^ . "Reviewed: Pinteaux, E, 2010-05-17"^^ . "Authored: Ray, KP, 2010-05-17"^^ . "IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably -3. Phosphorylation enhances the E3 ligase activity of Pellino-1 in conjunction with several different E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b). Phosphorylation at any of several different sites or a combination of other sites leads to full activation of Pellino-1 E3 ubiquitin ligase activity.

Though not shown here, the current models of IRAK1 involvement suggest it is part of a complex that includes TRAF6."^^ . . . . . . . "IRAK1 and 4 can phosphorylate Pellino-1 and 2."^^ . "2.7.11"^^ . . . . .