. "Authored: Garapati, P V, 2011-01-18"^^ . "Edited: Garapati, P V, 2011-01-18"^^ . "Reviewed: Zhang, DE, 2011--0-2-"^^ . "The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation."^^ . . . . . . . . . "ISGylation of IRF3"^^ . "6.3.2.19"^^ . . . . . . . . .