. "Authored: Garapati, P V, 2011-01-18"^^ . "Edited: Garapati, P V, 2011-01-18"^^ . "Reviewed: Zhang, DE, 2011--0-2-"^^ . "Ubiquitin ligase UBE1L is the ISG15 activating enzyme. UBE1L activates ISG15 in an ATP-dependent process that links UBE1L to ISG15 via a thioester bond. Arginine 153 (R153) in human ISG15 is identified as the key residue for ISG15 and UBE1L's interaction."^^ . . . . . . . "Activation of ISG15 by UBE1L E1 ligase"^^ . "6.3.2.19"^^ . . . . . . .